A preseason Super Bowl favorite has been upset in the first regular season game to take place in Australia. The 49ers secured a 27-7 victory over the Rams. This win marks a significant start to the season for the 49ers, who dominated their opponents.

The game's outcome is a notable one, given the Rams' status as a preseason favorite. Further details about the game are available from the source.

The final score of 27-7 reflects the 49ers' strong performance against the Rams in this historic matchup in Australia.